Journal of Translational and Practical Medicine regularly publishes internationally qualified issues in the field of Medicine in the light of up-to-date information.

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Original Article
Ocular pulse amplitude and hemodynamy in controlled asymmetric glaucoma: a cross-sectional study
Aims: The aim of this study was to explore the relationship between glaucoma severity, ocular pulse amplitude (OPA) and hemodynamic variables.
Methods: Thirty-one Asymmetric primary open-angle glaucoma (POAG) cases (one eye with better-MD, fellow eye with worst-MD) who applied to the glaucoma outpatient clinic of Gulhane Military Medical Faculty Hospital between January 1, 2006 and June 30, 2007 were included in this cross- sectional study. Patients using beta-blockers or alphaadrenergic agonists were excluded. The patients went on using glaucoma medications. Asymmetricity was assessed if a visual field mean deviation (MD) difference ?6 decibel existed between the eyes. Mean MD and pattern standard deviation, diurnal OPA and intraocular pressure(IOP) (7 am, 9 am, 11 am, 1 pm, 3 pm, 5 pm, 7 pm, 9 pm, 11 pm, 1 am, 4 am), central corneal thickness, peak systolic velocity (PSV), end diastolic velocity (EDV), PSV/EDV , pulsatility index (PI), resistivity index (RI) for internal carotid artery and ophthalmic artery were measured with color Doppler ultrasonography.
Results: The differences in mean diurnal IOP and mean diurnal OPA between the eyes were statistically insignificant. Each diurnal IOP and OPA values and coefficient of variability of diurnal IOP and OPA were statistically insignificant between the groups. There was no significant difference in PSV , EDV , PSV/EDV , PI and RI between the better-MD and worse-MD eyes. The correlations between mean IOP/mean OPA, each diurnal IOP/OPA values were insignificant.
Conclusion: These results suggest that ocular hemodynamy is affected after a critical point in the evolution of glaucoma. The severity of glaucoma is not directly related to pulsatile ocular blood flow.

1. Kac MJ, Solari HP , Velarde GC, Brazuna R, Cardoso GP , Ventura MP . Ocular pulse amplitude in patients with asymmetric primary open-angle glaucoma. Curr Eye Res 2011; 36: 727-32.
2. Agarwal HC, Gupta V , Sihota R, Singh K. Pulsatile ocular blood flow among normal subjects and patients with high tension glaucoma. Indian J Ophthalmol 2003; 51: 133-8.
3. Cioffi GA, Alm A. Measurement of ocular blood flow. J Glaucoma 2001; 10: S62-4.
4. Emre M, Orgul S, Gugleta K, Flammer J. Ocular blood flow alteration in glaucoma is related to systemic vascular dysregulation. Br J Ophthalmol 2004; 88: 662-6.
5. Fontana L, Poinoosawmy D, Bunce CV , O'Brien C, Hitchings RA. Pulsatile ocular blood flow investigation in asymmetric normal tension glaucoma and normal subjects. Br J Ophthalmol 1998; 82: 731-6.
6. Kanngiesser HE, Kniestedt C, Robert YC. Dynamic contour tonometry: presentation of a new tonometer. J Glaucoma 2005; 14: 344-50.
7. Schwenn O, Troost R, Vogel A, Grus F, Beck S, Pfeiffer N. Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension. Br J Ophthalmol 2002; 86: 981-4.
8. Hoffmann EM, Grus FH, Pfeiffer N. Intraocular pressure and ocular pulse amplitude using dynamic contour tonometry and contact lens tonometry. BMC Ophthalmol 2004; 4: 4.
9. Flammer J, Orgul S, Costa VP, et al. The impact of ocular blood flow in glaucoma. Progress in retinal and eye research 2002; 21: 359-93.
10. Flammer J, Orgul S. Optic nerve blood-flow abnormalities in glaucoma. Prog Retin Eye Res 1998; 17: 267-89.
11. Plange N, Bienert M, Remky A, Arend KO. Optic disc fluorescein leakage and intraocular pressure in primary open-angle glaucoma. Current eye research 2012; 37: 508-12.
12. Knecht PB, Bosch MM, Menke MN, Bachmann LM, Funk J, Kaufmann C. Dynamic contour tonometry: handheld versus slit-lamp-mounted. Ophthalmology 2009; 116: 1450-4.
13. O'Brien C, Saxton V, Crick RP, Meire H. Doppler carotid artery studies in asymmetric glaucoma. Eye (Lond) 1992; 6: 273-6.
14. Stalmans I, Harris A, Vanbellinghen V , Zeyen T, Siesky B. Ocular pulse amplitude in normal tension and primary open angle glaucoma. J Glaucoma 2008; 17: 403-7.
15. Drance SM, Wheeler C, Pattullo M. Uniocular open-angle glaucoma. Am J Ophthalmol 1968; 65: 891-902.
16. Feldman F, Sweeney VP , Drance SM. Cerebro-vascular studies in chronic simple glaucoma. Can J Ophthalmol 1969; 4: 358-64.
17. Jampol LM, Miller NR. Carotid artery disease and glaucoma. Br J Ophthalmol 1978; 62: 324-6.
18. Flammer J. Psychophysical mechanisms and treatment of vasospastic disorders in normal-tension glaucoma. Bulletin de la Societe belge d'ophtalmologie 1992; 244: 129-34.
19. Goff MJ, Kerrison JB. Bilateral simultaneous anterior ischemic optic neuropathy in a young, healthy man. Arch Ophthalmol 2003; 121: 1652-3.
20. Schmidt KG, von Ruckmann A, Pillunat LE. Topical carbonic anhydrase inhibition increases ocular pulse amplitude in high tension primary open angle glaucoma. Br J Ophthalmol 1998; 82: 758-62.
21. Zhang MZ, Fu ZF, Liu XR, Zheng C. [A comparison study of pulsitile ocular blood flow in normal eyes and primary open angle glaucoma]. Zhonghua Y an Ke Za Zhi 2004; 40: 250-3.
22. Romppainen T, Kniestedt C, Bachmann LM, Sturmer J. [Ocular pulse amplitude: a new biometrical parameter for the diagnose of glaucoma?]. Ophthalmologe 2007; 104: 230-5.
23. Punjabi OS, Ho HK, Kniestedt C, Bostrom AG, Stamper RL, Lin SC. Intraocular pressure and ocular pulse amplitude comparisons in different types of glaucoma using dynamic contour tonometry. Curr Eye Res 2006; 31: 851-62.
24. Vulsteke C, Stalmans I, Fieuws S, Zeyen T. Correlation between ocular pulse amplitude measured by dynamic contour tonometer and visual field defects. Graefes Arch Clin Exp Ophthalmol 2008; 246: 559-65.
25. Trew DR, Smith SE. Postural studies in pulsatile ocular blood flow: II. Chronic open angle glaucoma. Br J Ophthalmol 1991; 75: 71-5.
26. Levine RA, Demirel S, Fan J, et al. Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study. Invest Ophthalmol Vis Sci 2006; 47: 3896-903.
27. Topouzis F, Wilson MR, Harris A, et al. Risk factors for primary open-angle glaucoma and pseudoexfoliative glaucoma in the Thessaloniki eye study. Am J Ophthalmol 2011; 152: 219-28.
28. Khatri A, Shrestha JK, Thapa M, Khatri BK, Kharel M. Severity of primary open-angle glaucoma in patients with hypertension and diabetes. Diabetes Metab Syndr Obes 2018; 11: 209-15.
Volume 1, Issue 2, 2022
Page : 43-48