JTPM

Journal of Translational and Practical Medicine regularly publishes internationally qualified issues in the field of Medicine in the light of up-to-date information.

EndNote Style
Index
Original Article
Evaluation of changes in skin sebum and moisture content with treatment in children with atopic dermatitis
Aims: Since the deterioration of the skin barrier plays a role in the development of atopic dermatitis, it is necessary to investigate the moisture and sebum content of the skin. In this context, our study aimed to evaluate the change of skin sebum and moisture content with treatment in children with atopic dermatitis.
Methods: This study is a cohort study. Patients aged 0-18 years, diagnosed with atopic dermatitis, and those who did not have any accompanying skin disease were included. Skin moisture and sebum levels were measured with a portable pen-shaped LCD Display Digital Skin Moist Oil Analyzer (Reyoung-Beauty, Guangdong, China) digital skin moisture and sebum measurement device from the cubital fossa before and 1 month after the treatment. Skin sebum and moisture were obtained as percentages.
Results: The median values of skin moisture and sebum content before treatment in 55 atopic dermatitis patients were 30.0 % (10.0-55.0) and 24.0% (16.0-49.0), respectively. The percentages of skin moisture and sebum content after treatment were 38.0 % (15.0-60.0) and 28.0 % (18.0-50.0), respectively. In atopic dermatitis patients, the increase in skin moisture and sebum percentages was statistically significant for both (p<0.001 and p=0.022, respectively)
Conclusion: Skin moisture and skin sebum contents improved significantly with treatment in children with atopic dermatitis. This situation highlights the importance of adherence to treatment and continuity of selected treatments in patients.


1. Grobe W, Bieber T, Novak N. Pathophysiology of atopicdermatitis. J Dtsch Dermatol Ges. 2019;17(4):433- 40.
2. Weidinger S, Novak N. Atopic dermatitis. Lancet.2016;387(10023):1109-1122.
3. Lyons JJ, Milner JD, Stone KD. Atopic dermatitis in children:clinical features, pathophysiology, and treatment. ImmunolAllergy Clin North Am. 2015;35(1):161-183.
4. Theodosiou G, Montgomery S, Metsini A, Dalgard FJ,Svensson &Aring;, Kobyletzki LB. Burden of atopic dermatitis inSwedish adults: a population-based study. Acta Derm Venereol.2019; 99(11): 964-970.
5. Flohr C, Mann J. New insights into the epidemiology ofchildhood atopic dermatitis. Allergy. 2014; 69(1): 3-16.
6. Bylund S, von Kobyletzki LB, Svalstedt M, Svensson &Aring;. Prevalenceand incidence of atopic dermatitis: a systematic review. ActaDerm Venereol. 2020;100(12):320-9.
7. Chambers ES, Vukmanovic-Stejic M. Skin barrier immunity andageing. Immunology. 2020;160(2):116-25.
8. Yang G, Seok JK, Kang HC, Cho Y-Y, Lee HS, Lee JY. Skin barrierabnormalities and immune dysfunction in atopic dermatitis. Int JMol Sci. 2020; 21(8):2867.
9. Leung DY, Berdyshev E, Goleva E. Cutaneous barrier dysfunctionin allergic diseases. J Allergy Clin Immunol. 2020;145(6):1485-97.
10. Boer M, Duchnik E, Maleszka R, Marchlewicz M. Structuraland biophysical characteristics of human skin in maintainingproper epidermal barrier function. Postepy Dermatol Alergol.2016;33(1):1-5.
11. Peng W, Novak N. Pathogenesis of atopic dermatitis. Clin ExpAllergy. 2015;45(3):566-74.
12. Darlenski R, Fluhr JW. Influence of skin type, race, sex, andanatomic location on epidermal barrier function. Clin Dermatol.2012;30(3):269-73.
13. Potts RO, Buras Jr EM, Chrisman Jr DA. Changes with age in themoisture content of human skin. J Invest Dermatol. 1984;82(1):97-100.
14. Sator P-G, Schmidt JB, H&ouml;nigsmann H. Comparison ofepidermal hydration and skin surface lipids in healthy individualsand in patients with atopic dermatitis. J Am Acad Dermatol.2003;48(3):352-8.
15. G&uuml;neş H, Nazik H, &Ouml;zkars MY, et al. The assessment of skinsebum and moisture content of infants with atopic dermatitis.Turk J Med Sci. 2020;50(4):844-8.
16. Krysiak ZJ, Stachewicz U. Electrospun fibers as carriers fortopical drug delivery and release in skin bandages and patchesfor atopic dermatitis treatment. Wiley Interdiscip Rev NanomedNanobiotechnol. 2023;15(1):e1829.
17. Nygaard U, Deleuran M, Vestergaard C. Emerging treatmentoptions in atopic dermatitis: topical therapies. Dermatology.2018;233(5):333-43.
18. Oranje AP, Glazenburg EJ, Wolkerstorfer A, de Waard-van derSpek FB. Practical issues on interpretation of scoring atopicdermatitis: the SCORAD index, objective SCORAD and thethree-item severity score. Br J Dermatol. 2007;157(4):645-648.
19. Stalder JF, Ta&iuml;eb A, Atherton DJ, et al. Severity scoring of atopicdermatitis: The SCORAD index: Consensus report of theeuropean task force on atopic dermatitis. Dermatology. 1993;186(1): 23-31.
20. Chovatiya R, Silverberg JI. Pathophysiology of atopic dermatitisand psoriasis: implications for management in children. Children.2019;6(10):108.
21. Frantz T, Wright EG, Balogh EA, Cline A, Adler-Neal AL,Feldman SR. Topical and oral therapies for childhood atopicdermatitis and plaque psoriasis. Children. 2019;6(11):125.
22. Slattery MJ, Essex MJ, Paletz EM, et al. Depression, anxiety, anddermatologic quality of life in adolescents with atopic dermatitis.J Allergy Clin Immunol. 2011; 128(3):668-671.
23. Egawa M, Koizumi K, Hirao T. Changes in facial moisturedistribution and feelings of moisture/dryness among variousenvironmental temperatures and humidities in summer andwinter. Skin Res Technol. 2020;26(6):937-48.
24. Bumbacea RS, Corcea SL, Ali S, Dinica LC, Fanfaret IS, Boda D.Mite allergy and atopic dermatitis: Is there a clear link? Exp TherMed. 2020;20(4):3554-60.
25. Evangelista MTP, Abad-Casintahan F, Lopez-Villafuerte L.The effect of topical virgin coconut oil on SCORAD index,transepidermal water loss, and skin capacitance in mild tomoderate pediatric atopic dermatitis: a randomized, double-blind, clinical trial. Int J Dermatol. 2014;53(1):100-8.
26. Brunner PM, Khattri S, Garcet S, et al. A mild topical steroidleads to progressive anti-inflammatory effects in the skin ofpatients with moderate-to-severe atopic dermatitis. J Allergy ClinImmunol. 2016;138(1):169-178.
27. Lyakhovitsky A, Barzilai A, Heyman R, et al. Low-dosemethotrexate treatment for moderate-to-severe atopic dermatitisin adults. J Eur Acad Dermatol Venereol. 2010;24(1):43-49.
28. Kim BE, Leung DY. Significance of skin barrier dysfunction inatopic dermatitis. Allergy Asthma Immunol Res. 2018;10(3):207-15.
29. Eichenfield LF, Tom WL, Berger TG, et al. Guidelines of care forthe management of atopic dermatitis: Section 2. Managementand treatment of atopic dermatitis with topical therapies. J AmAcad Dermatol. 2014;71(1): 116-132.
30. Atherton DJ. Topical corticosteroids in atopic dermatitis. BMJ.2003;327(7421):942-3.
31. Kempers S, Boguniewicz M, Carter E, et al. A randomizedinvestigator-blinded study comparing pimecrolimus cream 1%with tacrolimus ointment 0.03% in the treatment of pediatricpatients with moderate atopic dermatitis. J Am Acad Dermatol.2004;51:515-525.
32. Hultsch T, Kapp A, Spergel J. Immunomodulation and safetyof topical calcineurin inhibitors for the treatment of atopicdermatitis. Dermatology. 2005;211(2):174-87.
Volume 2, Issue 2, 2023
Page : 53-59
_Footer